Brain Scan might Predict Therapy for Obsessive-Compulsive Disorder

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HealthDay News – Human brain scans may predict which kind of therapy will be most reliable for obsessive-compulsive condition (OCD) in teens and grownups, in accordance with a scholarly research published online Aug. 28 in The American Journal of Psychiatry.

Luke J. Norman, Ph.D., from University of Michigan in Ann Arbor, and co-workers randomly assigned 87 sufferers with OCD (a long time, 12 to 45 years; 57 women) to get 12 days of cognitive behavioral treatment (CBT) or stress management treatment (SMT; active control). Before therapy, useful magnetic resonance imaging scans had been conducted in patients performing a motivation flanker task.

The researchers discovered that within the CBT group, an improved treatment response was significantly connected with greater pretreatment activation within the proper temporal lobe and rostral anterior cingulate cortex during cognitive handle and within the ventromedial prefrontal, orbitofrontal, lateral prefrontal, and amygdala areas during reward processing. Reduced pretreatment activation in a overlapping group of regions was of a better treatment reaction to SMT significantly.

“Such treatment-specific associations are essential for the growth of biomarkers to personalize therapy in OCD,” the authors compose.